Correlations between long-term PPI use and increasing risk of Esophageal cancer

A study from Sweden has shown that a long-term maintenance therapy with PPI was associated with an increased risk for esophageal cancer, even in patients taking PPIs for indications not previously associated with this cancer risk.

“To assess generalizability and validity of these results, further investigations in other settings with other distributions of risk factors for oesophageal cancer is necessary,” they write. “Yet, we believe that a more restrictive attitude towards maintenance use of PPIs may be indicated…. Long term use of PPIs should be addressed with caution.”

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The study was published online February 22 in Cancer Epidemiology

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