Very-Low-Volume Bowel Prep for Colonoscopy

One of the biggest burdens of colonoscopy is bowel preparation. Plenvu (NER1006) is a low-volume polyethylene glycol-based solution with electrolytes which can be successfully used as pre-colonoscopy cleansing preparation, as an alternative to standard volume or other low-volume prep solutions.

The 1-liter prep has shown superiority over other low-volume prep options in several studies, being the lowest-volume bowel prep solution and the best alternative for patients who have difficulty tolerating standard preparations in terms of cleaning efficacy and adverse effects.

Plenvu was noninferior/outperformed MoviePrep (2 liter PEG + ascorbate) – MORA study (UEG Journal 2016), a trisulfate bowel cleansing solution – NOCT study (Gastrointest Endosc 2017), a sodium picosulfate and magnesium salt solution – DAYB study (Endoscopy 2018).

[1] Bisschops R, et al. P0179. Efficacy and safety of the novel 1L PEG and ascorbate bowel preparation NER1006 versus standard 2L PEG with ascorbate in overnight or morning split-dosing administration: results from the phase 3 study MORA. UEG Journal 2016; 4(5S): A218 – A219.

[2] DeMicco MP Clayton LB, Pilot J et al.  Novel 1 L polyethylene glycol-based bowel preparation NER1006 for overall and right-sided colon cleansing: a randomized controlled phase 3 trial versus trisulfate. Gastrointest Endosc 2017; 87(3):677-687.
[3] Schreiber, et al. P1266. Colon cleansing efficacy and safety with 1L NER1006 versus sodium picosulfate with magnesium citrate: a randomized phase 3 trial. Endoscopy 2018;

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